Re-Lax - Causes Isaac to spawn poops behind him while he walks for a few seconds. Power Pill - Gives you invulnerability and the ability to damage enemies for a short while (similar to The Gamekid effect) Unlocked from Challenge #24 - PAY TO PLAY Percs - Causes Isaac to only take half a heart of damage from all sources for the current room (The Wafer effect). One makes you larger - Increases Isaac's size, but does not affect the size of his hitbox One makes you smaller - Reduces Isaac's size and hitbox size If there are no enemies this pill spawns 1-3 blue spiders instead Infested? - Spawns one blue attack spider for every enemy in the room. Infested! - Destroys all poops in the room and spawns a blue attack spider on every destroyed poop Unlocked from Challenge #24 - PAY TO PLAYįriends till the end - Spawns three friendly blue attack flies Lemon Party - Spawns a large yellow pool on the floor around you, damaging enemies which walk in itĪddicted - Causes you to take a full heart of damage for all sources for the current room. I found pills - Changes the appearance of Isaac's face for the current room (Cosmetic change only) I can see forever - Opens secret room and super secret room entrances on the current floor Hematemesis - Empties all but one red heart container and spawns 1-4 red hearts on the floor If you have 1 or less heart containers, this pill becomes Health Up Can be negated with Black Candleīad Gas - Isaac farts, poisoning enemies around himīombs are key - Switches number of bombs and keysĮxplosive Diarrhea - Spawns five live troll bombs behind Isaac, one per secondįull Health - Restores all your empty red heart containers Can be used with Placebo to generate infinite batteriesĪmnesia - Hides the floor map for the rest of the current floor (same as curse of the lost). The Lost will not see items that are detrimental or useless for him, rather than just no health up items.48 Hour Energy - Fully recharges your active item and drops 1-2 battery pickups.Eden spawns three random items that can come from any pool, and can pick one to take.Eve gains the effects of Whore of Babylon regardless of her health and has Dead Bird following her without taking damage.Judas gains The Book of Belial as a passive item that combines with any activated item, dealing damage to nearby enemies and granting a damage boost that scales with the number of charges that the item has, as well as having unique synergies with some items.Cain gains +1 Luck and spawns an upgraded Arcade on every floor.Magdalene gains a single red Heart container but increases her maximum number of hearts to 18.Isaac had a slight alteration, having pedestals swap between two items rather than spawning two pedestals.When Birthright was ported into Repentance, only ?, Bethany, and Jacob & Esau retained their Birthright functionality. ![]() The reference is strengthened by the Birthright's specific effect when taken by Jacob or Esau, allowing them to "inherit" the items of their brother.
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